Investigating how certain brain receptors affect brain function in Fragile X Syndrome
Examining the role of specific NMDA receptor subunits in cortical circuit dysfunction in Fragile X Syndrome
This study is looking at how certain brain receptors might affect people with Fragile X Syndrome and autism, especially regarding their sensitivity to sensory experiences, and it aims to find new ways to help improve brain function through testing different treatments.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project ID | NIH-10926838 on NIH RePORTER |
What this research studies
This research explores the role of specific NMDA receptor subunits in the brain's cortical circuits, particularly in individuals with Fragile X Syndrome (FXS) and autism. By examining brain activity patterns through EEG studies and using animal models, the research aims to understand how these receptor subunits contribute to sensory hypersensitivity and circuit dysfunction. The approach involves testing various compounds that can modulate the activity of these receptors to see if they can restore normal brain function. This could lead to new insights into treatment options for those affected by FXS.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with Fragile X Syndrome or autism who experience sensory hypersensitivity.
Not a fit: Patients without Fragile X Syndrome or autism, or those who do not experience sensory hypersensitivity, may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for sensory hypersensitivity and cognitive challenges in patients with Fragile X Syndrome and autism.
How similar studies have performed: Previous research has shown promising results in understanding NMDA receptor functions in related conditions, suggesting potential for success in this novel approach.
Where this research is happening
Dallas, United States
- Ut Southwestern Medical Center — Dallas, United States (Active)
Researchers
- Principal investigator: Shedd, Aleya Michelle — Ut Southwestern Medical Center
- Study coordinator: Shedd, Aleya Michelle
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.