Investigating how certain brain proteins are altered by specific microRNAs in Alzheimer's disease and diabetes.
Brain protein alteration by vascular overexpressed miRNA (BravomiR)
This study is looking at how certain tiny molecules in the brain might connect Alzheimer's disease and type 2 diabetes, with the hope of finding new ways to help people who have both conditions.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Indiana University Indianapolis NIH-funded |
| Lab location | 1 site (Indianapolis, United States) |
| Project ID | NIH-10392051 on NIH RePORTER |
What this research studies
This research focuses on understanding the relationship between Alzheimer's disease (AD) and type 2 diabetes (T2D) by exploring how specific microRNAs (miRNAs) influence brain protein alterations. The study aims to identify shared regulatory pathways between these two conditions, which could lead to new treatment strategies. By examining the dysregulation of miR146a and miR200b in both AD and T2D, the research seeks to uncover mechanisms that contribute to the progression of these diseases. Patients may benefit from insights that could inform co-treatment approaches for those suffering from both conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Alzheimer's disease, particularly those who also have type 2 diabetes or pre-diabetes.
Not a fit: Patients who do not have Alzheimer's disease or type 2 diabetes may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies for patients with Alzheimer's disease and type 2 diabetes.
How similar studies have performed: Previous research has shown promising results in exploring the connections between diabetes and Alzheimer's disease, suggesting that this approach could yield valuable insights.
Where this research is happening
Indianapolis, United States
- Indiana University Indianapolis — Indianapolis, United States (Active)
Researchers
- Principal investigator: Lahiri, Debomoy K — Indiana University Indianapolis
- Study coordinator: Lahiri, Debomoy K
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.