Investigating how certain brain circuits function in autism models
Physiological and molecular mechanisms of impaired PV circuit homeostasis in Autism mouse models
['FUNDING_FELLOWSHIP'] · UNIVERSITY OF CALIFORNIA BERKELEY · NIH-11030833
This study is looking at how certain brain cells, called parvalbumin neurons, might not work the way they should in people with autism, which can make it hard for them to process sensory information, and it's using mice to help figure this out so we can find better ways to help.
Quick facts
| Phase | ['FUNDING_FELLOWSHIP'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA BERKELEY (nih funded) |
| Locations | 1 site (BERKELEY, UNITED STATES) |
| Trial ID | NIH-11030833 on ClinicalTrials.gov |
What this research studies
This research explores the role of parvalbumin (PV) neurons in autism spectrum disorders (ASD) by examining how these neurons may not function properly, affecting sensory processing. Using mouse models of autism, the study will measure the excitability of PV neurons and how they respond to changes in sensory input. The goal is to understand the underlying mechanisms that lead to sensory processing issues in individuals with ASD, which could inform future treatments.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with autism spectrum disorder, particularly those experiencing sensory processing challenges.
Not a fit: Patients without autism spectrum disorder or those not experiencing sensory processing issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights and potential therapies for improving sensory processing in individuals with autism.
How similar studies have performed: Previous research has indicated that understanding the mechanisms of sensory processing in autism can lead to significant advancements in treatment, suggesting this approach has potential for success.
Where this research is happening
BERKELEY, UNITED STATES
- UNIVERSITY OF CALIFORNIA BERKELEY — BERKELEY, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MONDAY, HANNAH — UNIVERSITY OF CALIFORNIA BERKELEY
- Study coordinator: MONDAY, HANNAH
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: autism spectral disorder, autism spectrum disorder, Autistic Disorder, autistic spectrum disorder