Investigating how certain brain circuits function in autism models
Official title: Physiological and molecular mechanisms of impaired PV circuit homeostasis in Autism mouse models
Funded at University of California Berkeley · NIH-11030833 · Data updated 2026-11-12
This study is looking at how certain brain cells, called parvalbumin neurons, might not work the way they should in people with autism, which can make it hard for them to process sensory information, and it's using mice to help figure this out so we can find better ways to help.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Berkeley NIH-funded |
| Lab location | 1 site (Berkeley, United States) |
| Project start | February 1, 2023 |
| Project end | October 31, 2025 |
| Funding year | 2025 |
| Award (this year) | $60,688 |
| NIH project number | 5F32NS126310-03 |
| Project ID | NIH-11030833 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with autism spectrum disorder, particularly those experiencing sensory processing challenges.
✕Less likely to help
Patients without autism spectrum disorder or those not experiencing sensory processing issues may not benefit from this research.
What this research studies
This research explores the role of parvalbumin (PV) neurons in autism spectrum disorders (ASD) by examining how these neurons may not function properly, affecting sensory processing. Using mouse models of autism, the study will measure the excitability of PV neurons and how they respond to changes in sensory input. The goal is to understand the underlying mechanisms that lead to sensory processing issues in individuals with ASD, which could inform future treatments.
Why it matters
Potential benefit: If successful, this research could lead to new insights and potential therapies for improving sensory processing in individuals with autism.
How similar studies have gone: Previous research has indicated that understanding the mechanisms of sensory processing in autism can lead to significant advancements in treatment, suggesting this approach has potential for success.
Where this research is happening
-
University of California Berkeley
Berkeley, United States Active
Researchers
- Principal investigator: Monday, Hannah — University of California Berkeley
- Study coordinator: Monday, Hannah
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.