Investigating how certain brain cells may protect against Alzheimer's disease in diverse populations
Elucidating changes in astrocyte subpopulations associated with resistance to Alzheimers Disease pathology in multi-ethnic cohorts
This study is looking at special brain cells called astrocytes in people who have signs of Alzheimer's but aren't experiencing memory problems, to find out what makes some people more resilient to the disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10794976 on NIH RePORTER |
What this research studies
This research explores the role of astrocytes, a type of brain cell, in individuals who show signs of Alzheimer's disease pathology but do not experience cognitive decline. By analyzing brain tissue from a diverse group of participants, the study aims to identify specific astrocyte subpopulations and their molecular characteristics that may contribute to cognitive resilience. Using advanced techniques like RNA sequencing and spatial transcriptomics, researchers will create a detailed map of these cells across different brain regions. This could help in understanding why some individuals are resistant to the cognitive effects of Alzheimer's disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals from diverse ethnic backgrounds who have been diagnosed with Alzheimer's disease or exhibit related pathology but maintain cognitive function.
Not a fit: Patients who are already experiencing significant cognitive decline or do not have any Alzheimer's disease pathology may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating cognitive decline in Alzheimer's disease.
How similar studies have performed: Previous research has indicated that certain brain cell types may play protective roles in cognitive resilience, but this study aims to expand on those findings in a more diverse population.
Where this research is happening
New York, United States
- Columbia University Health Sciences — New York, United States (Active)
Researchers
- Principal investigator: Menon, Vilas — Columbia University Health Sciences
- Study coordinator: Menon, Vilas
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.