Investigating how certain bacteria attach to human cells
Allosteric adhesins of enterobacterial pathogens
This study is looking at how certain proteins help bacteria like E. coli and Salmonella stick to our cells, which could help us find new ways to treat infections caused by these germs.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-11078246 on NIH RePORTER |
What this research studies
This research focuses on understanding the allosteric properties of adhesins in various human enterobacterial pathogens, such as E. coli and Salmonella. By examining how these proteins can switch between active and inactive states, the research aims to uncover mechanisms that allow bacteria to effectively bind to host cells. The study will utilize advanced techniques to identify other adhesins that may function similarly to the well-studied FimH protein. This could lead to insights into bacterial adhesion processes and potential therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who are at risk of infections caused by enterobacterial pathogens, particularly those with compromised immune systems or underlying health conditions.
Not a fit: Patients who are not affected by enterobacterial infections or do not have risk factors for such infections may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing bacterial infections by disrupting their ability to adhere to human tissues.
How similar studies have performed: While the specific focus on allosteric properties of bacterial adhesins is novel, similar research has shown success in understanding bacterial adhesion mechanisms and developing targeted therapies.
Where this research is happening
Seattle, United States
- University of Washington — Seattle, United States (Active)
Researchers
- Principal investigator: Sokurenko, Evgeni Veniaminovic — University of Washington
- Study coordinator: Sokurenko, Evgeni Veniaminovic
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.