Investigating how certain bacteria and proteins contribute to colorectal cancer
Official title: Microbial and host biomarkers in colorectal cancer oncogenesis
Funded at Columbia University Health Sciences · NIH-11133253 · Data updated 2026-11-12
This study is looking at how a specific bacteria and a protein in the body might work together to influence the growth of colorectal cancer, especially when the body is under stress, with the goal of finding new ways to diagnose and treat this type of cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | April 1, 2025 |
| Project end | March 31, 2030 |
| Funding year | 2025 |
| Award (this year) | $600,499 |
| NIH project number | 1R01CA292464-01A1 |
| Project ID | NIH-11133253 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals at risk for colorectal cancer or those diagnosed with the disease.
✕Less likely to help
Patients with colorectal cancer who do not have the specific bacterial or protein markers being studied may not benefit from this research.
What this research studies
This research focuses on understanding the role of Fusobacterium nucleatum, a type of bacteria, and a protein called Annexin A1 in the development of colorectal cancer. The study aims to explore how these factors interact and contribute to cancer growth, particularly under stress conditions. By examining the biochemical changes in these components, the researchers hope to identify new biomarkers that could help in diagnosing and treating colorectal cancer more effectively.
Why it matters
Potential benefit: If successful, this research could lead to new diagnostic tools and therapies for colorectal cancer, improving patient outcomes.
How similar studies have gone: Previous research has shown promising results in understanding the role of microbes in cancer, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Columbia University Health Sciences
New York, United States Active
Researchers
- Principal investigator: Han, Yiping — Columbia University Health Sciences
- Study coordinator: Han, Yiping
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.