Investigating how certain bacteria and mucus can prevent nasal colonization by Staphylococcus aureus
Official title: Effect of Mucins and Dolosigranlulum pigrum on Staphylococcus aureus nasal colonization
Funded at Baylor College of Medicine · NIH-10886514 · Data updated 2026-11-12
This study is looking for new ways to stop the common germ Staphylococcus aureus from settling in your nose, which can cause infections, by exploring how certain natural substances and helpful bacteria can work together to keep it away.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor College of Medicine NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | July 1, 2023 |
| Project end | June 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $48,974 |
| NIH project number | 5F31AI172324-02 |
| Project ID | NIH-10886514 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults who are carriers of Staphylococcus aureus or are at risk of developing related infections.
✕Less likely to help
Patients who do not carry Staphylococcus aureus or have no risk factors for related infections may not benefit from this research.
What this research studies
This research focuses on finding nonantibiotic methods to prevent nasal colonization by Staphylococcus aureus, a common bacterium that can lead to serious infections. The study aims to identify the role of mucins and the beneficial bacterium Dolosigranulum pigrum in reducing S. aureus colonization. Using human nasal epithelial organoids, researchers will explore how these factors interact to influence bacterial behavior in the nasal passages. The goal is to develop new strategies that could help lower the risk of infections associated with S. aureus.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments that prevent S. aureus infections without relying on antibiotics.
How similar studies have gone: Previous research has shown promising results in using beneficial bacteria to combat harmful bacterial colonization, indicating potential success for this approach.
Where this research is happening
-
Baylor College of Medicine
Houston, United States Active
Researchers
- Principal investigator: Boyd, Andrea Ivey — Baylor College of Medicine
- Study coordinator: Boyd, Andrea Ivey
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.