Investigating how certain antioxidants may help treat sepsis
Official title: The Role of Plasmalogen Mitochondrial and Endothelial Antioxidant Properties in Sepsis
Funded at Saint Louis University · NIH-11006257 · Data updated 2026-11-12
This study is looking at how a special type of antioxidant called plasmalogens might help people with sepsis, a serious infection that can harm organs, by reducing stress on their cells and improving their overall health.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Saint Louis University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project start | September 30, 2023 |
| Project end | September 29, 2027 |
| Funding year | 2024 |
| Award (this year) | $53,974 |
| NIH project number | 5F30HL170694-02 |
| Project ID | NIH-11006257 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with sepsis, particularly those experiencing severe symptoms and complications.
✕Less likely to help
Patients with mild infections that do not progress to sepsis may not benefit from this research.
What this research studies
This research focuses on understanding the role of plasmalogens, a type of antioxidant, in the treatment of sepsis, a severe condition caused by infections that can lead to organ failure. The study aims to explore how these antioxidants can mitigate oxidative stress and improve mitochondrial health in patients suffering from sepsis. By examining the levels of plasmalogens in the blood and their effects on cellular health, the research seeks to identify new therapeutic strategies that could enhance patient outcomes. The approach involves both laboratory studies and clinical observations to gather comprehensive data on the effectiveness of plasmalogens in sepsis management.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that significantly improve recovery rates and reduce complications for patients with sepsis.
How similar studies have gone: While the specific role of plasmalogens in sepsis is a novel approach, previous studies have shown promise in using antioxidants to mitigate oxidative stress in various conditions.
Where this research is happening
-
Saint Louis University
Saint Louis, United States Active
Researchers
- Principal investigator: Mcguffee, Reagan — Saint Louis University
- Study coordinator: Mcguffee, Reagan
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.