Investigating how certain antigens affect the immune response and vaccine development for Valley Fever.
Early in vivo expressed antigens and their role in virulence, immune response, and vaccines for coccidioidomycosis
['FUNDING_OTHER'] · NORTHERN ARIZONA UNIVERSITY · NIH-10899655
This study is looking at how certain proteins from the Valley Fever fungus affect the immune system in mice, with the hope of finding new ways to create vaccines and better treatments for people dealing with this illness.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | NORTHERN ARIZONA UNIVERSITY (nih funded) |
| Locations | 1 site (FLAGSTAFF, UNITED STATES) |
| Trial ID | NIH-10899655 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the role of specific antigens produced by the Coccidioides fungi, which cause Valley Fever. By analyzing how these antigens interact with the immune system in live animal models, the researchers aim to uncover mechanisms of virulence and identify potential targets for new vaccines. The study employs advanced genomic techniques to assess gene expression in infected mouse lungs, providing insights that in vitro studies cannot offer. This approach could lead to improved diagnostic tools and treatment strategies for patients affected by this disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at risk of or diagnosed with coccidioidomycosis, particularly those living in endemic areas.
Not a fit: Patients with other fungal infections or those not exposed to Coccidioides species may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of effective vaccines and treatments for Valley Fever, significantly improving patient outcomes.
How similar studies have performed: Previous research has shown promise in understanding fungal pathogens through genomic analysis, indicating potential for success in this novel approach.
Where this research is happening
FLAGSTAFF, UNITED STATES
- NORTHERN ARIZONA UNIVERSITY — FLAGSTAFF, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BARKER, BRIDGET MARIE — NORTHERN ARIZONA UNIVERSITY
- Study coordinator: BARKER, BRIDGET MARIE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.