Investigating how cerebrospinal fluid clearance changes with aging and Alzheimer's disease
Understanding CSF Clearance in Aging and Alzheimerâs Brain Through Dynamic Sodium MRI - Resubmission - 1
This study is looking at how aging and Alzheimer's disease affect the flow of cerebrospinal fluid in the brain, using special imaging techniques to compare healthy people with those who have Alzheimer's, in hopes of finding ways to improve brain health as we age.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University School of Medicine NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11056840 on NIH RePORTER |
What this research studies
This research aims to understand how the clearance of cerebrospinal fluid (CSF) is affected by aging and Alzheimer's disease (AD). It will utilize advanced imaging techniques, including dynamic sodium MRI and ultrashort echo time proton MRI, to measure CSF flow and production in the brain. By comparing these measurements in healthy individuals and those with AD, the study seeks to uncover the mechanisms behind CSF clearance and its relationship to amyloid beta deposition. This could provide insights into potential interventions for improving brain health in aging populations.
Who could benefit from this research
Good fit: Ideal candidates for this research include adults aged 21 and older, particularly those experiencing cognitive decline or at risk for Alzheimer's disease.
Not a fit: Patients with neurological conditions unrelated to Alzheimer's disease or those under 21 years old may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating Alzheimer's disease by enhancing CSF clearance.
How similar studies have performed: Previous studies in animal models have shown promising results regarding CSF clearance and its implications for Alzheimer's disease, but this research aims to explore these effects in humans, making it a novel approach.
Where this research is happening
New York, United States
- New York University School of Medicine — New York, United States (Active)
Researchers
- Principal investigator: Qian, Yongxian — New York University School of Medicine
- Study coordinator: Qian, Yongxian
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.