Investigating how ceramide affects cell behavior and death in cancer cells
Ceramide Activated Protein Phosphatases
['FUNDING_R01'] · STATE UNIVERSITY NEW YORK STONY BROOK · NIH-10886804
This study is looking at how a fat molecule called ceramide affects how cancer cells respond to stress and whether they grow or die, with the goal of finding new ways to understand and treat cancer.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | STATE UNIVERSITY NEW YORK STONY BROOK (nih funded) |
| Locations | 1 site (STONY BROOK, UNITED STATES) |
| Trial ID | NIH-10886804 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the role of ceramide, a lipid molecule, in regulating stress responses and the growth or death of cancer cells. The team aims to identify specific pathways and mechanisms by which ceramide activates certain proteins that influence cell adhesion and migration. They will develop a novel assay to measure ceramide levels at the plasma membrane and explore how ceramide generation is stimulated. By defining these processes, the research seeks to uncover new insights into cancer cell behavior.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with cancer who may benefit from therapies targeting ceramide pathways.
Not a fit: Patients with non-cancerous conditions or those not affected by ceramide-related pathways may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for targeting cancer cell behavior and improving treatment outcomes.
How similar studies have performed: Previous research has shown promising results in understanding lipid signaling in cancer, suggesting that this approach could yield valuable insights.
Where this research is happening
STONY BROOK, UNITED STATES
- STATE UNIVERSITY NEW YORK STONY BROOK — STONY BROOK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: HANNUN, YUSUF AWNI — STATE UNIVERSITY NEW YORK STONY BROOK
- Study coordinator: HANNUN, YUSUF AWNI
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.