Investigating how centriole connections affect vision and hearing loss
Official title: The role of centriole linkage in retinal degeneration and hearing loss
Funded at University of Utah · NIH-11025390 · Data updated 2026-11-12
This study is looking at how certain gene changes affect both vision and hearing by using special mice that have problems with their eyesight and hearing, which could help us understand conditions like retinitis pigmentosa and Usher syndrome better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Utah NIH-funded |
| Lab location | 1 site (Salt Lake City, United States) |
| Project start | March 1, 2025 |
| Project end | February 28, 2030 |
| Funding year | 2025 |
| Award (this year) | $462,430 |
| NIH project number | 1R01EY036877-01 |
| Project ID | NIH-11025390 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with retinitis pigmentosa, Usher syndrome, or related genetic conditions causing vision and hearing impairments.
✕Less likely to help
Patients with hearing or vision loss due to non-genetic factors may not benefit from this research.
What this research studies
This research explores the role of centriole linkages in the biology of photoreceptors, which are crucial for vision, and their connection to hearing loss. By studying specific genes associated with conditions like retinitis pigmentosa and Usher syndrome, the research aims to uncover the mechanisms behind these diseases. The team has developed mutant mice that exhibit both vision and hearing impairments to analyze the effects of disrupted centriole connections on cellular function. This approach could lead to a better understanding of how these genetic mutations contribute to sensory deficits.
Why it matters
Potential benefit: If successful, this research could lead to new therapies for patients suffering from vision and hearing loss due to genetic mutations.
How similar studies have gone: While the specific approach of studying centriole linkages in this context is novel, related research has shown promise in understanding genetic causes of sensory deficits.
Where this research is happening
-
University of Utah
Salt Lake City, United States Active
Researchers
- Principal investigator: Yang, Jun — University of Utah
- Study coordinator: Yang, Jun
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.