Investigating how cellular stress affects bladder function in older adults
Regulation of Detrusor Overactivity by Cellular Stress in Bladder Ischemia
This study is looking at how reduced blood flow affects bladder function in older adults, especially veterans, to find ways to improve bothersome urinary symptoms and help people feel better.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | VA Boston Health Care System NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10477977 on NIH RePORTER |
What this research studies
This research focuses on understanding how reduced blood flow (ischemia) impacts bladder function, particularly in older adults. It aims to explore the role of cellular stress responses in preventing or reversing bladder dysfunction, which can lead to bothersome urinary symptoms. The study will involve examining the prevalence of lower urinary tract symptoms (LUTS) among veterans, especially those who do not have common causes like prostate enlargement. By targeting specific cellular pathways, the research seeks to improve quality of life for those affected by these symptoms.
Who could benefit from this research
Good fit: Ideal candidates for this research are elderly individuals, particularly veterans, experiencing lower urinary tract symptoms without bladder outlet obstruction.
Not a fit: Patients who have bladder dysfunction solely due to bladder outlet obstruction or other non-ischemic causes may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that alleviate urinary symptoms and improve the quality of life for older adults.
How similar studies have performed: Previous research has indicated that targeting cellular stress pathways may be effective in addressing bladder dysfunction, suggesting a promising avenue for this investigation.
Where this research is happening
Boston, United States
- VA Boston Health Care System — Boston, United States (Active)
Researchers
- Principal investigator: Azadzoi, Kazem M — VA Boston Health Care System
- Study coordinator: Azadzoi, Kazem M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.