Investigating how cellular aging affects heart artery function after cancer treatment
Official title: Translational studies of cellular senescence as a regulator of doxorubicin-mediated arterial dysfunction
Funded at University of Colorado Denver · NIH-11110406 · Data updated 2026-11-12
This study is looking at how aging cells might affect heart and blood vessel problems caused by the chemotherapy drug Doxorubicin, starting with tests in mice and eventually involving cancer survivors to find ways to help prevent these issues.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project start | June 10, 2024 |
| Project end | May 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $248,999 |
| NIH project number | 5R00HL159241-04 |
| Project ID | NIH-11110406 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include cancer survivors who have undergone treatment with Doxorubicin and are experiencing cardiovascular issues.
✕Less likely to help
Patients who have not received Doxorubicin or do not have cardiovascular concerns may not benefit from this research.
What this research studies
This research focuses on understanding how cellular senescence, or aging of cells, influences arterial dysfunction caused by the chemotherapy drug Doxorubicin. The study will begin with experiments in mice to confirm the relationship between Doxorubicin and arterial issues, followed by plans to translate findings to human subjects. The research aims to identify mechanisms that lead to cardiovascular problems in cancer survivors, potentially leading to new therapeutic strategies. Patients may be involved in studies that explore how to mitigate these effects.
Why it matters
Potential benefit: If successful, this research could lead to improved cardiovascular health for cancer survivors who have received Doxorubicin.
How similar studies have gone: Previous research has shown promising results in understanding the effects of cellular senescence on cardiovascular health, indicating that this approach may yield valuable insights.
Where this research is happening
-
University of Colorado Denver
Aurora, United States Active
Researchers
- Principal investigator: Clayton, Zachary S. — University of Colorado Denver
- Study coordinator: Clayton, Zachary S.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.