Investigating how cells transition through different stages of pluripotency during early development
Understanding the mechanism of pre- to naïve- to formative- pluripotency transitions
This study is looking at how certain cells in early embryos change as they develop, which could help us understand why some pregnancies don’t go as planned, and it aims to find ways to support couples dealing with infertility related to these early stages of development.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston Children's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11130660 on NIH RePORTER |
What this research studies
This research focuses on understanding the critical transitions of pluripotent cells during early embryonic development, particularly how these cells change from pre-pluripotent to naïve and then to formative states. By studying the molecular and cellular mechanisms involved in these transitions, the research aims to uncover the reasons behind developmental abnormalities that can lead to pregnancy loss. The approach includes using in vitro embryonic stem cell culture systems to replicate these developmental stages, allowing for detailed analysis of the factors influencing pluripotency. This could provide insights into improving outcomes for couples facing infertility issues related to early embryonic development.
Who could benefit from this research
Good fit: Ideal candidates for this research are couples who have experienced recurrent pregnancy loss or infertility related to early embryonic development.
Not a fit: Patients who are not experiencing pregnancy loss or infertility issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and potential interventions for couples experiencing pregnancy loss due to early developmental issues.
How similar studies have performed: While this research explores a complex area of embryonic development, similar studies have shown promise in understanding pluripotency and its implications for reproductive health.
Where this research is happening
Boston, United States
- Boston Children's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Zhang, Yi — Boston Children's Hospital
- Study coordinator: Zhang, Yi
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.