Investigating how cells respond to misfolded proteins
Next generation gene expression analysis
['FUNDING_OTHER'] · NEW YORK UNIVERSITY · NIH-11087685
This study is looking at how our cells react when proteins don't fold properly, which can cause conditions like ALS, to find new ways to help treat these diseases.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | NEW YORK UNIVERSITY (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-11087685 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the cellular response to misfolded proteins, which can lead to diseases like Amyotrophic Lateral Sclerosis (ALS). By analyzing gene expression and the Unfolded Protein Response (UPR), the study aims to uncover how cells manage stress caused by these proteins. The researchers will profile changes in gene regulation and protein modifications to identify potential therapeutic targets. Patients may benefit from insights that could lead to new treatments for neurodegenerative diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with neurodegenerative diseases, particularly those with ALS.
Not a fit: Patients with conditions unrelated to protein misfolding or neurodegeneration may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating neurodegenerative diseases like ALS.
How similar studies have performed: Previous research has shown promising results in understanding the UPR and its implications in neurodegenerative diseases, indicating that this approach has potential for success.
Where this research is happening
NEW YORK, UNITED STATES
- NEW YORK UNIVERSITY — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: VOGEL, CHRISTINE — NEW YORK UNIVERSITY
- Study coordinator: VOGEL, CHRISTINE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Amyotrophic Lateral Sclerosis Motor Neuron Disease