Investigating how cells respond to DNA replication stress
Understanding Replication Stress Response in Mammalian Cells
This study is looking at how our cells deal with problems that can happen when they copy their DNA, especially focusing on a special protein called RTF2 that helps keep things running smoothly, with the hope that understanding this process can help prevent issues like cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rockefeller University NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10907550 on NIH RePORTER |
What this research studies
This research focuses on understanding how mammalian cells manage challenges during DNA replication, particularly when they encounter barriers that can lead to errors and instability. The team has identified a key protein, RTF2, that plays a crucial role in this process. By studying how RTF2 is regulated and removed from stalled replication forks, the research aims to uncover mechanisms that could help prevent genome instability and cancer. The approach involves advanced cellular models and assays to analyze the interactions and responses of various proteins involved in DNA replication.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with cancers that exhibit high levels of genomic instability or those undergoing treatments that affect DNA replication.
Not a fit: Patients with stable, non-cancerous conditions or those not affected by DNA replication issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for improving cancer treatments by enhancing the stability of DNA replication in cells.
How similar studies have performed: Previous research has shown success in understanding DNA damage responses, but the specific role of RTF2 in replication stress is a novel area of investigation.
Where this research is happening
New York, United States
- Rockefeller University — New York, United States (Active)
Researchers
- Principal investigator: Smogorzewska, Agata — Rockefeller University
- Study coordinator: Smogorzewska, Agata
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.