Investigating how cells repair dangerous DNA breaks and the effects on genome stability
Double strand break repair maelstrom: causes, mechanisms and genome destabilizing consequences
This study is looking at how cells fix serious DNA damage that can lead to cancer, using a special type of yeast to learn more about the risky repair methods that might cause problems, all to help us better understand DNA repair in our health.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Science Center NIH-funded |
| Lab location | 1 site (San Antonio, United States) |
| Project ID | NIH-11139528 on NIH RePORTER |
What this research studies
This research focuses on understanding how cells repair double-strand DNA breaks, which are critical for cell survival and genomic stability. The study examines various repair mechanisms, particularly those that can lead to mutations and chromosomal rearrangements associated with cancer. Using a specialized yeast model, researchers will explore two high-risk repair pathways that can destabilize the genome. The findings aim to inform future studies and improve our understanding of DNA repair processes in human health.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with genetic predispositions to cancers or those with conditions related to DNA repair deficiencies.
Not a fit: Patients with stable genomes and no history of genetic disorders or cancers may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating cancers linked to DNA repair failures.
How similar studies have performed: Previous research has shown success in understanding DNA repair mechanisms, but this specific approach to studying high-risk pathways is relatively novel.
Where this research is happening
San Antonio, United States
- University of Texas Hlth Science Center — San Antonio, United States (Active)
Researchers
- Principal investigator: Malkova, Anna L — University of Texas Hlth Science Center
- Study coordinator: Malkova, Anna L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.