Investigating how cells repair damaged DNA to prevent cancer
Official title: Core 2: Chromosome Replication and Analysis (CRA) Core
Funded at University of Texas Hlth Science Center · NIH-10847792 · Data updated 2026-11-12
This study is looking at how cells fix serious DNA damage that can cause cancer, using special tools to change certain proteins and see how those changes affect the repair process, with the hope of finding better treatments for cancer.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Science Center NIH-funded |
| Lab location | 1 site (San Antonio, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $248,376 |
| NIH project number | 1P01CA275717-01A1 |
| Project ID | NIH-10847792 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with a family history of breast cancer or known mutations in BRCA1 or BRCA2 genes.
✕Less likely to help
Patients without genetic predispositions to DNA repair deficiencies or those not affected by related cancers may not benefit from this research.
What this research studies
This research focuses on understanding the mechanisms by which cells repair DNA double-strand breaks and damaged replication forks, which can lead to chromosome abnormalities and cancer. It utilizes advanced techniques such as CRISPR/Cas9 to create specific mutations in key proteins involved in DNA repair, allowing researchers to analyze how these mutations affect cellular processes. The study aims to improve our understanding of the biochemical regulation of DNA repair pathways and their impact on chromosomal stability and cell survival, which is crucial for developing new cancer therapies.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing and treating cancers associated with DNA repair deficiencies.
How similar studies have gone: Previous research has shown promising results in understanding DNA repair mechanisms, indicating that this approach could lead to significant advancements in cancer treatment.
Where this research is happening
-
University of Texas Hlth Science Center
San Antonio, United States Active
Researchers
- Principal investigator: Hromas, Robert a — University of Texas Hlth Science Center
- Study coordinator: Hromas, Robert a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.