Investigating how cells interact with blood vessels in pulmonary hypertension
Evaluation of the Dynamic Reciprocity Between Cells and the Vessel Matrix in Pulmonary Hypertension
This study is looking at how inflammation and certain proteins affect the blood vessels in the lungs of people with pulmonary hypertension, hoping to find clues that could lead to better treatments for patients with this condition.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project ID | NIH-10911064 on NIH RePORTER |
What this research studies
This research explores the role of inflammation and complement activation in pulmonary hypertension (PH), focusing on how these factors contribute to changes in the blood vessels of the lungs. By examining tissue samples from patients with idiopathic pulmonary arterial hypertension (IPAH) and using animal models, the study aims to identify specific molecular patterns that indicate disease severity. The research employs advanced techniques in genomics and proteomics to analyze lung tissue and blood plasma, seeking to understand the underlying mechanisms of vascular remodeling in PH. Patients may benefit from insights that could lead to more targeted therapies for this condition.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with idiopathic pulmonary arterial hypertension (IPAH) and those with related pulmonary vascular diseases.
Not a fit: Patients with pulmonary hypertension due to other causes, such as left heart disease or chronic lung disease, may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new, more effective treatments for pulmonary hypertension by identifying specific molecular targets.
How similar studies have performed: Previous research has shown promising results in understanding the role of inflammation in pulmonary hypertension, suggesting that this approach could yield valuable insights.
Where this research is happening
Aurora, UNITED STATES
- University of Colorado Denver — Aurora, United States (Active)
Researchers
- Principal investigator: Tuder, Rubin M. — University of Colorado Denver
- Study coordinator: Tuder, Rubin M.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.