Investigating how cells form cilia, important structures for cell signaling.
Official title: Understanding the molecular mechanisms of cilia formation
Funded at University of Oklahoma Hlth Sciences Ctr · NIH-10915554 · Data updated 2026-11-12
This study is looking into how tiny structures called primary cilia form in our cells and how problems with this process can lead to health issues like obesity and vision loss, with the hope that understanding these details will help find better treatments for people affected by these conditions.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Oklahoma Hlth Sciences Ctr NIH-funded |
| Lab location | 1 site (Oklahoma City, United States) |
| Project start | September 1, 2023 |
| Project end | July 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $362,500 |
| NIH project number | 5R35GM151013-02 |
| Project ID | NIH-10915554 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research include individuals affected by ciliopathies or related disorders.
✕Less likely to help
Patients with conditions unrelated to cilia dysfunction may not receive any benefit from this research.
What this research studies
This research focuses on understanding the molecular mechanisms behind the formation of primary cilia, which are essential for cell signaling in many human cells. The project examines how ciliary vesicles are recruited and fused to form cilia, and how dysfunction in these processes can lead to various disorders known as ciliopathies, including obesity and retinal degeneration. By identifying specific markers for ciliary vesicles, the research aims to clarify the steps involved in cilia formation and their role in cellular function. Patients may benefit from insights gained into how cilia-related disorders develop and how they might be treated.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for ciliopathies and improve understanding of related health conditions.
How similar studies have gone: While the specific approach of this research is novel, similar studies have shown promise in understanding cilia-related disorders.
Where this research is happening
-
University of Oklahoma Hlth Sciences Ctr
Oklahoma City, United States Active
Researchers
- Principal investigator: Kanie, Tomoharu — University of Oklahoma Hlth Sciences Ctr
- Study coordinator: Kanie, Tomoharu
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.