Investigating how cells and genes affect inflammation in the eye
Cells and genes that govern inflammation in the subretinal space
['FUNDING_R21'] · UNIVERSITY OF MICHIGAN AT ANN ARBOR · NIH-10837715
This study is looking at how inflammation affects the eye when important light-sensing cells start to die, using zebrafish to learn more about how the eye can heal itself and what new cell types are involved, which could help us find better treatments for eye diseases.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF MICHIGAN AT ANN ARBOR (nih funded) |
| Locations | 1 site (ANN ARBOR, UNITED STATES) |
| Trial ID | NIH-10837715 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the mechanisms behind inflammation in the subretinal space, particularly during the death of photoreceptors, which are crucial for vision. By using zebrafish, which can regenerate retinal cells, the study aims to identify new cell types and their roles in inflammation and regeneration. The research will explore how retinal pigment epithelium (RPE) influences inflammation and will analyze the genetic signatures of specific microglia involved in this process. This could provide insights into potential therapeutic strategies for retinal diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing retinal degeneration or diseases that affect photoreceptors.
Not a fit: Patients with retinal conditions that do not involve inflammation or photoreceptor death may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that promote retinal regeneration and restore vision in patients with retinal diseases.
How similar studies have performed: Previous research has shown promise in using regenerative approaches in zebrafish, indicating potential for success in this novel investigation.
Where this research is happening
ANN ARBOR, UNITED STATES
- UNIVERSITY OF MICHIGAN AT ANN ARBOR — ANN ARBOR, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: HITCHCOCK, PETER F — UNIVERSITY OF MICHIGAN AT ANN ARBOR
- Study coordinator: HITCHCOCK, PETER F
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Disorder