Investigating how cells and genes affect inflammation in the eye
Official title: Cells and genes that govern inflammation in the subretinal space
Funded at University of Michigan at Ann Arbor · NIH-10837715 · Data updated 2026-11-12
This study is looking at how inflammation affects the eye when important light-sensing cells start to die, using zebrafish to learn more about how the eye can heal itself and what new cell types are involved, which could help us find better treatments for eye diseases.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project start | June 1, 2023 |
| Project end | September 30, 2025 |
| Funding year | 2024 |
| Award (this year) | $234,000 |
| NIH project number | 5R21EY034182-02 |
| Project ID | NIH-10837715 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals experiencing retinal degeneration or diseases that affect photoreceptors.
✕Less likely to help
Patients with retinal conditions that do not involve inflammation or photoreceptor death may not benefit from this research.
What this research studies
This research focuses on understanding the mechanisms behind inflammation in the subretinal space, particularly during the death of photoreceptors, which are crucial for vision. By using zebrafish, which can regenerate retinal cells, the study aims to identify new cell types and their roles in inflammation and regeneration. The research will explore how retinal pigment epithelium (RPE) influences inflammation and will analyze the genetic signatures of specific microglia involved in this process. This could provide insights into potential therapeutic strategies for retinal diseases.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that promote retinal regeneration and restore vision in patients with retinal diseases.
How similar studies have gone: Previous research has shown promise in using regenerative approaches in zebrafish, indicating potential for success in this novel investigation.
Where this research is happening
-
University of Michigan at Ann Arbor
Ann Arbor, United States Active
Researchers
- Principal investigator: Hitchcock, Peter F — University of Michigan at Ann Arbor
- Study coordinator: Hitchcock, Peter F
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.