Investigating how cell signaling affects development and disease
Official title: G protein-coupled receptor signaling in development and disease: Hedgehog and beyond
Funded at University of Utah · NIH-11135357 · Data updated 2026-11-12
This study is looking at how certain proteins on cell surfaces help cells understand signals from their surroundings, which is really important for healthy growth and organ formation, and it aims to find ways to fix problems in this communication that can lead to diseases.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Utah NIH-funded |
| Lab location | 1 site (Salt Lake City, United States) |
| Project start | August 7, 2019 |
| Project end | May 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $415,800 |
| NIH project number | 5R35GM133672-07 |
| Project ID | NIH-11135357 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with conditions related to abnormal cell signaling, such as certain cancers or developmental disorders.
✕Less likely to help
Patients with conditions unrelated to G protein-coupled receptor signaling may not benefit from this research.
What this research studies
This research explores how proteins on cell surfaces communicate signals from the outside environment to the inside of the cell, which is crucial for proper development and health. It focuses on the Hedgehog signaling pathway, which plays a vital role in the formation of organs and maintaining balance in the body. The researchers aim to understand how these signals are received and processed, and how disruptions in this signaling can lead to diseases. By uncovering these mechanisms, they hope to develop new therapeutic strategies to correct abnormal signaling.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments for diseases caused by faulty cell signaling.
How similar studies have gone: Previous research has shown promising results in understanding GPCR signaling pathways, indicating potential for success in this area.
Where this research is happening
-
University of Utah
Salt Lake City, United States Active
Researchers
- Principal investigator: Myers, Benjamin — University of Utah
- Study coordinator: Myers, Benjamin
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.