Investigating how cell signaling affects abdominal aortic aneurysms
Renewal: Pannexin-1 signaling in abdominal aortic aneurysms
['FUNDING_R01'] · UNIVERSITY OF FLORIDA · NIH-10840414
This study is looking into how inflammation and cell death contribute to abdominal aortic aneurysms (AAA), with the hope of finding new ways to treat this serious condition that currently has limited options for patients.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF FLORIDA (nih funded) |
| Locations | 1 site (GAINESVILLE, UNITED STATES) |
| Trial ID | NIH-10840414 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the mechanisms behind abdominal aortic aneurysms (AAA), which can lead to life-threatening aortic ruptures. It examines how inflammation and cell death processes, particularly through a signaling pathway involving pannexin-1 channels, contribute to the development of AAA. By studying how the body clears dead cells and the role of specific receptors in this process, the research aims to uncover potential therapeutic targets. Patients may benefit from insights that could lead to new treatments for AAA, a condition currently lacking effective medical interventions.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with abdominal aortic aneurysms or those at high risk for developing this condition.
Not a fit: Patients who do not have abdominal aortic aneurysms or related vascular conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatment options for patients suffering from abdominal aortic aneurysms.
How similar studies have performed: Previous research has shown promising results in understanding the role of cell signaling in vascular diseases, suggesting that this approach may yield valuable insights.
Where this research is happening
GAINESVILLE, UNITED STATES
- UNIVERSITY OF FLORIDA — GAINESVILLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: UPCHURCH, GILBERT RIVERS — UNIVERSITY OF FLORIDA
- Study coordinator: UPCHURCH, GILBERT RIVERS
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.