Investigating how cell division affects tissue health and cancer development
Basal Cell Polarity Proteins in Normal Tissue Homeostasis and Cancer
['FUNDING_R01'] · FRED HUTCHINSON CANCER CENTER · NIH-10667590
This study is looking at how certain cells in our body help keep our tissues healthy by dividing in a special way, and it aims to find out how problems in this process might lead to cancer, which could help develop new treatments for patients.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | FRED HUTCHINSON CANCER CENTER (nih funded) |
| Locations | 1 site (SEATTLE, UNITED STATES) |
| Trial ID | NIH-10667590 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding how adult stem and progenitor cells maintain normal tissue health through a specialized type of cell division called asymmetric cell division. It examines how these cells use both internal mechanisms and signals from their environment to produce two different daughter cells: one that continues to divide and another that differentiates and stops dividing. By studying the role of specific proteins in this process, the research aims to uncover how disruptions in cell division can lead to cancer. Patients may benefit from insights gained about cancer stem cells and potential new therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults with cancers related to abnormal cell division, particularly those with squamous cell carcinoma.
Not a fit: Patients with cancers unrelated to the mechanisms of asymmetric cell division may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating cancers by targeting the mechanisms of cell division.
How similar studies have performed: Previous studies in model organisms have shown success in understanding the role of cell polarity in cancer, suggesting that this approach may yield valuable insights in humans as well.
Where this research is happening
SEATTLE, UNITED STATES
- FRED HUTCHINSON CANCER CENTER — SEATTLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: VASIOUKHIN, VALERI — FRED HUTCHINSON CANCER CENTER
- Study coordinator: VASIOUKHIN, VALERI
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.