Investigating how cell communication affects damage from HIV in the brain
Targeting cell-to-cell communication to prevent bystander damage mediated by viral reservoirs
['FUNDING_R01'] · UNIVERSITY OF TEXAS MED BR GALVESTON · NIH-11088913
This study is looking at how HIV can harm brain cells even when the virus isn't actively spreading, and it's for people living with HIV who may be experiencing problems with thinking or movement; the researchers want to find ways to protect healthy brain cells and improve treatment options.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF TEXAS MED BR GALVESTON (nih funded) |
| Locations | 1 site (GALVESTON, UNITED STATES) |
| Trial ID | NIH-11088913 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding how HIV affects communication between brain cells, particularly astrocytes, which can lead to damage even when the virus is not actively replicating. The study aims to explore the mechanisms behind this bystander damage caused by viral reservoirs in the central nervous system. By examining the role of specific channels that facilitate cell communication, the researchers hope to identify new strategies to protect uninfected brain cells from harm. This could lead to improved treatment approaches for individuals living with HIV-related cognitive and motor impairments.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV who are undergoing antiretroviral therapy and may experience cognitive or motor impairments.
Not a fit: Patients who are not living with HIV or those who do not experience any neurological symptoms may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that prevent cognitive and motor impairments in individuals living with HIV.
How similar studies have performed: While the approach of targeting cell communication in the context of HIV is innovative, similar studies have shown promise in understanding viral reservoirs and their impact on brain health.
Where this research is happening
GALVESTON, UNITED STATES
- UNIVERSITY OF TEXAS MED BR GALVESTON — GALVESTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: EUGENIN, ELISEO A — UNIVERSITY OF TEXAS MED BR GALVESTON
- Study coordinator: EUGENIN, ELISEO A
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired Immune Deficiency Syndrome Virus, Acquired Immunodeficiency Syndrome Virus