Investigating how cell aging affects health and potential treatments
Cytoplasmic chromatin fragments in cell senescence - novel mechanisms and interventions
This study is looking at how aging cells can cause inflammation and health issues, and it aims to find safer ways to help people age better without affecting their body's ability to fight off tumors.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sanford Burnham Prebys Medical Discovery Institute NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-11023097 on NIH RePORTER |
What this research studies
This research focuses on understanding cellular senescence, a process that contributes to aging and age-related diseases. It explores how damaged cells stop dividing and release inflammatory signals, which can lead to chronic inflammation and tissue aging. The study aims to identify mechanisms that activate these signals and to develop safer treatments that inhibit their harmful effects without compromising the body's ability to suppress tumors. By targeting these processes, the research seeks to promote healthier aging.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults experiencing age-related health issues or chronic inflammation.
Not a fit: Patients who are not experiencing age-related conditions or chronic inflammation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that improve health during aging by reducing inflammation and preventing age-related diseases.
How similar studies have performed: Previous research has shown promise in targeting cellular senescence and its effects, indicating that this approach could lead to significant advancements in aging-related therapies.
Where this research is happening
La Jolla, United States
- Sanford Burnham Prebys Medical Discovery Institute — La Jolla, United States (Active)
Researchers
- Principal investigator: Adams, Peter D. — Sanford Burnham Prebys Medical Discovery Institute
- Study coordinator: Adams, Peter D.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.