Investigating how cell-adhesion receptors work and their role in diseases
Structural and Functional Studies of Cell-Adhesion Receptors
['FUNDING_OTHER'] · UNIVERSITY OF CHICAGO · NIH-11007168
This study is looking at special proteins on cell surfaces that help cells communicate, which are important for the development of the nervous system, bones, and heart, to find out how they work and how they might be used to treat diseases like cancer and developmental disorders.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CHICAGO (nih funded) |
| Locations | 1 site (CHICAGO, UNITED STATES) |
| Trial ID | NIH-11007168 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the structure and function of specific cell-surface receptors that are crucial for cellular communication. These receptors, known as adhesion G Protein-Coupled Receptors and teneurins, play significant roles in the development of the nervous system, skeletal system, and heart. The study employs a combination of structural analysis, biochemical assays, and protein engineering to uncover how these receptors are activated and how they can be targeted for therapeutic purposes. By exploring these mechanisms, the research aims to provide insights into their involvement in diseases such as cancer and developmental disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals affected by conditions such as cancer, developmental disorders, or brain malformations.
Not a fit: Patients with conditions unrelated to cell-adhesion receptor dysfunction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating various diseases linked to cell-adhesion receptors.
How similar studies have performed: Previous research has shown promise in understanding similar cell-surface receptors, indicating potential for success in this area.
Where this research is happening
CHICAGO, UNITED STATES
- UNIVERSITY OF CHICAGO — CHICAGO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ARAC-OZKAN, DEMET — UNIVERSITY OF CHICAGO
- Study coordinator: ARAC-OZKAN, DEMET
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.