Investigating how CD38 affects immune activation in women with HIV
CD38 intensifies immune activation in women living with HIV (the CIGNAL study)
['FUNDING_R21'] · UNIVERSITY OF MARYLAND BALTIMORE · NIH-10872841
This study is looking at how a protein called CD38 affects the immune system in women with HIV, to understand why they may face more health challenges than men, even when on treatment, and it involves giving blood samples to help find better ways to support their health.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF MARYLAND BALTIMORE (nih funded) |
| Locations | 1 site (BALTIMORE, UNITED STATES) |
| Trial ID | NIH-10872841 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the role of CD38, a protein that influences immune activation, in women living with HIV. It aims to explore why women experience higher rates of disease progression and mortality compared to men, even when receiving antiretroviral therapy (ART). By examining immune responses and cellular markers in women, the study seeks to identify potential therapeutic targets that could improve health outcomes. Participants will provide blood samples to analyze the immune system's response to HIV.
Who could benefit from this research
Good fit: Ideal candidates for this research are women aged 21 and older who are living with HIV.
Not a fit: Patients who are not women or those who are not living with HIV may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments and health outcomes for women living with HIV.
How similar studies have performed: Previous research has indicated that understanding immune activation in HIV can lead to significant advancements in treatment, suggesting this approach has potential for success.
Where this research is happening
BALTIMORE, UNITED STATES
- UNIVERSITY OF MARYLAND BALTIMORE — BALTIMORE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MATHUR, POONAM — UNIVERSITY OF MARYLAND BALTIMORE
- Study coordinator: MATHUR, POONAM
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired Immune Deficiency Syndrome, Acquired Immune Deficiency Syndrome Virus, Acquired Immunodeficiency Syndrome, Acquired Immunodeficiency Syndrome Virus