Investigating how CD200 signaling affects immune cell interactions in stroke.
Official title: CD200 signaling mediates the interactions of neurons and endothelia with circulating leukocytes in stroke
Funded at University of Texas Hlth Sci Ctr Houston · NIH-11092785 · Data updated 2026-11-12
This study is looking at how a protein called CD200 can help calm down the immune system after a stroke, which might reduce brain damage and improve recovery.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Sci Ctr Houston NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | June 1, 2023 |
| Project end | May 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $561,996 |
| NIH project number | 5R01NS129977-03 |
| Project ID | NIH-11092785 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults aged 21 and older who have experienced a stroke.
✕Less likely to help
Patients who have not had a stroke or are under 21 years old may not benefit from this research.
What this research studies
This research explores the role of CD200 signaling in the immune response following a stroke. It aims to understand how CD200 interacts with its receptor on immune cells to potentially reduce harmful immune activation that can worsen brain injury. By manipulating CD200 and its receptor in mouse models, the study will assess how these interactions influence the behavior of immune cells and the extent of stroke damage. The findings could lead to new therapeutic strategies to protect the brain after a stroke.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that minimize brain damage and improve recovery after a stroke.
How similar studies have gone: Previous research has shown promise in targeting immune responses in stroke, suggesting that this approach could yield significant insights.
Where this research is happening
-
University of Texas Hlth Sci Ctr Houston
Houston, United States Active
Researchers
- Principal investigator: Liu, Fudong — University of Texas Hlth Sci Ctr Houston
- Study coordinator: Liu, Fudong
Related research
Other NIH-funded projects on the same topics.
-
Stroke prevention with hydroxyurea for children with sickle cell anemia in Nigeria
A multinational, patient-facing study tests whether hydroxyurea can safely prevent first strokes in Nigerian children with sickle cell anemia.
-
Music-powered tools to boost blood pressure and stroke prevention for Nigerian youth and their older caregivers
This project uses popular music to help Nigerian youths and their older family members start and stick to blood pressure and stroke prevention habits.
-
Determinants of Post-Stroke Cognitive Outcomes and Vascular Effects on Recovery
A large, multi-site effort aims to understand why some stroke survivors develop long-term cognitive problems and dementia, and how vascular health and pre-existing brain changes influence recovery.
-
LRP1 controls NSC movement and stroke recovery
This NIH grant studies how a brain receptor called LRP1 helps neural stem cells move to stroke injuries and support recovery in adults.
-
BBB Dysfunction after Stroke and Risk for Dementia
A study at Stanford will look at whether inflammation after a stroke leads to leaky blood vessels and later dementia, by following stroke survivors and comparing them with people without stroke.
-
Improving blood flow after stroke by breaking down NETs
Aims to see if breaking down neutrophil extracellular traps (NETs) after an ischemic stroke can improve blood flow and reduce brain injury in patients.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.