Investigating how CD1 molecules influence immune responses in certain T cells against cancer
Molecular and functional investigation of the role of CD1 in gamma delta T cell surveillance
This study is looking at how certain immune cells called γδ T cells work, especially in people with colorectal cancer, to better understand how they recognize and fight off infections and cancer, which could help develop new treatments.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project ID | NIH-10910036 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of CD1 molecules in the immune response, particularly how they interact with a specific type of T cells known as γδ T cells. These T cells are crucial for fighting infections and cancer, but the exact mechanisms of how they recognize antigens are not fully understood. The study will involve examining these T cells in both healthy and cancerous tissues, particularly in the context of colorectal cancer, to identify their functional characteristics and how they may be activated or expanded. By analyzing the T cell receptor (TCR) repertoire and other signals, the research aims to uncover important insights that could lead to new therapeutic strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with colorectal cancer or those with a strong interest in understanding immune responses related to this disease.
Not a fit: Patients with conditions unrelated to colorectal cancer or those who do not have a significant immune response may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance the immune system's ability to target and eliminate colorectal cancer cells.
How similar studies have performed: Other research has shown promising results in understanding immune responses through similar mechanisms, suggesting potential for success in this area.
Where this research is happening
Chicago, United States
- University of Chicago — Chicago, United States (Active)
Researchers
- Principal investigator: Adams, Erin June — University of Chicago
- Study coordinator: Adams, Erin June
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.