Investigating how CCL2 affects HIV-1 virus release and its potential as a drug target
CCL2-CCR2b signaling in HIV-1 fitness and disease; Role of host genetic polymorphisms
This study is looking at how a protein called CCL2 affects the release of the HIV virus from infected cells, which could help find new ways to treat HIV.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Albert Einstein College of Medicine NIH-funded |
| Lab location | 1 site (Bronx, United States) |
| Project ID | NIH-10843103 on NIH RePORTER |
What this research studies
This research focuses on understanding how a protein called CCL2 influences the release of the HIV-1 virus from infected cells. By studying the interactions between CCL2 and a protein known as ALIX, the researchers aim to uncover new mechanisms that could be targeted for HIV treatment. The project involves using genetically modified cells to observe how the absence of CCL2 affects virus production and the mobilization of ALIX. This could lead to the identification of new therapeutic strategies for managing HIV infection.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals living with HIV-1, particularly those infected with clade B strains of the virus.
Not a fit: Patients with HIV-1 clade C strains may not benefit from this research as the mechanisms being studied may not apply to their viral type.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve the management of HIV-1 infection.
How similar studies have performed: While the specific approach of targeting CCL2 and CCR2 for HIV treatment is novel, similar research has shown promise in understanding viral release mechanisms.
Where this research is happening
Bronx, United States
- Albert Einstein College of Medicine — Bronx, United States (Active)
Researchers
- Principal investigator: Prasad, Vinayaka R. — Albert Einstein College of Medicine
- Study coordinator: Prasad, Vinayaka R.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.