Investigating how carbohydrate enzymes in gut bacteria affect health

Carbohydrate enzyme gene clusters in human gut microbiome

NIH-funded research University of Nebraska Lincoln · NIH-10770533

This study is looking at how certain genes in gut bacteria help break down carbohydrates from our food, and it aims to find ways to tailor diets to improve health based on each person's unique gut bacteria.

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionUniversity of Nebraska Lincoln NIH-funded
Lab location1 site (Lincoln, United States)
Project IDNIH-10770533 on NIH RePORTER

What this research studies

This research focuses on understanding the role of carbohydrate enzyme gene clusters in the human gut microbiome and how they interact with diet to influence health. By developing advanced computational tools, the project aims to analyze the genetic makeup of gut microbes and their ability to break down different carbohydrates. This could lead to personalized nutrition strategies that optimize dietary choices based on individual gut microbiota profiles. The research will explore whether specific gut microbes can utilize certain dietary fibers and how these interactions can be harnessed for better health outcomes.

Who could benefit from this research

Good fit: Ideal candidates for this research are individuals interested in personalized nutrition and those with specific dietary needs or metabolic conditions.

Not a fit: Patients who do not have any interest in dietary changes or those with no metabolic health issues may not benefit from this research.

Why it matters

Potential benefit: If successful, this research could lead to personalized dietary recommendations that improve health by optimizing gut microbiome function.

How similar studies have performed: Previous research has shown promise in using bioinformatics to understand gut microbiome interactions with diet, indicating that this approach could yield valuable insights.

Where this research is happening

Lincoln, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.