Investigating how CAR T cell treatment affects the brain and causes neurological issues
Official title: Endothelial-Leukocyte Adhesion in CAR T Cell Treatment Associated Neurotoxicity
Funded at Seattle Children's Hospital · NIH-10932217 · Data updated 2026-11-12
This study is looking at how CAR T cell therapy, a treatment for some cancers, can sometimes cause brain problems by blocking blood flow, and it's using mice to find ways to make this treatment safer and better for patients like you.
Quick facts
| Grant type | R37 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Seattle Children's Hospital NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | September 22, 2023 |
| Project end | August 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $549,663 |
| NIH project number | 5R37CA275954-02 |
| Project ID | NIH-10932217 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children under 11 years old who are receiving CAR T cell therapy for leukemia or lymphoma.
✕Less likely to help
Patients who are not undergoing CAR T cell therapy or those with pre-existing neurological conditions may not benefit from this research.
What this research studies
This research focuses on understanding the neurological side effects that can occur after CAR T cell therapy, a treatment for certain types of cancer. The study uses a mouse model to explore how white blood cells can block blood vessels in the brain, leading to cognitive disturbances and other serious complications. By examining the molecular mechanisms behind this process, researchers aim to identify potential ways to mitigate these side effects. The findings could help improve the safety and effectiveness of CAR T cell therapy for patients.
Why it matters
Potential benefit: If successful, this research could lead to safer CAR T cell therapies with fewer neurological side effects for patients.
How similar studies have gone: While the specific mechanisms of neurotoxicity in CAR T cell therapy are still being explored, related research has shown promise in understanding cytokine release syndrome and its effects on the brain.
Where this research is happening
-
Seattle Children's Hospital
Seattle, United States Active
Researchers
- Principal investigator: Gust, Juliane — Seattle Children's Hospital
- Study coordinator: Gust, Juliane
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.