Investigating how cannabis affects genes in people living with HIV
Cell-type based epigenomic analysis to identify druggable genes for people living with HIV infection and using cannabis
This study is looking at how using cannabis might change the DNA of people living with HIV, especially in important immune cells, to see if it can help improve their treatment options.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-11035502 on NIH RePORTER |
What this research studies
This research explores the effects of cannabis use on the genetic makeup of individuals living with HIV. It focuses on understanding how cannabis may influence DNA methylation in specific cell types, particularly CD4+ T cells, which are crucial for immune function. By analyzing these changes, the study aims to identify potential therapeutic targets that could improve treatment outcomes for HIV patients. The research employs advanced techniques to dissect the epigenomic landscape and the interaction between HIV and cannabis.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV who also use cannabis.
Not a fit: Patients who do not use cannabis or are not living with HIV may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for managing HIV infection and its associated complications.
How similar studies have performed: While some studies have explored the effects of cannabis on HIV, this research takes a novel approach by focusing on cell-type specific epigenomic analysis.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Xu, Ke — Yale University
- Study coordinator: Xu, Ke
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.