Investigating how cannabinoids can reduce opioid tolerance and dependence
CB2 Cannabinoid Mechanisms for Suppressing Opioid Tolerance and Dependence
This study is looking at how certain cannabis compounds might help people who need long-term opioid pain relief by reducing the problems of getting used to the medication and experiencing withdrawal, with the hope of finding better ways to manage pain without the downsides of opioids.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Trustees of Indiana University NIH-funded |
| Lab location | 1 site (Bloomington, United States) |
| Project ID | NIH-10579196 on NIH RePORTER |
What this research studies
This research explores the interaction between CB2 cannabinoid receptors and mu opioid receptors to address two major issues with long-term opioid use: tolerance and physical dependence. By studying how certain cannabinoid compounds can prevent the development of tolerance and reduce withdrawal symptoms in preclinical models, the research aims to find new ways to enhance the effectiveness of opioids while minimizing their negative side effects. If successful, this could lead to improved pain management strategies for patients relying on opioids.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who are currently using opioids for severe pain management and may be at risk for developing tolerance or dependence.
Not a fit: Patients who are not using opioids or those who do not experience pain that requires opioid treatment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide patients with more effective pain management options that reduce the risk of tolerance and dependence on opioids.
How similar studies have performed: Previous studies have shown promising results with cannabinoid interactions in animal models, suggesting potential for success in translating these findings to human applications.
Where this research is happening
Bloomington, United States
- Trustees of Indiana University — Bloomington, United States (Active)
Researchers
- Principal investigator: Hohmann, Andrea Grace — Trustees of Indiana University
- Study coordinator: Hohmann, Andrea Grace
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.