Investigating how cannabinoids affect tobacco use and cravings
Official title: Effect of Cannabinoids on Tobacco Product Demand and Pharmacodynamics
Funded at Johns Hopkins University · NIH-11080314 · Data updated 2026-11-12
This study is looking at how using cannabis, especially THC, affects people's cravings for tobacco products like cigarettes and e-cigarettes, and it's for anyone interested in understanding the connection between these two substances.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | May 1, 2024 |
| Project end | February 28, 2029 |
| Funding year | 2025 |
| Award (this year) | $657,500 |
| NIH project number | 5R01DA058624-02 |
| Project ID | NIH-11080314 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation are individuals who use both cannabis and tobacco products.
✕Less likely to help
Patients who do not use cannabis or tobacco products may not benefit from this research.
What this research studies
This research explores the relationship between cannabis and tobacco use, focusing on how cannabinoids, particularly delta-9-tetrahydrocannabinol (THC), influence the desire to use tobacco products. By conducting laboratory studies, researchers will assess the effects of THC on the motivation and subjective experiences associated with smoking combustible cigarettes and using e-cigarettes. The goal is to understand the mechanisms behind co-use of these substances, which could inform public health policies aimed at reducing tobacco and cannabis dependence. Participants will be involved in experiments that measure their responses to different doses of THC and nicotine.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for reducing tobacco use and dependence among individuals who also use cannabis.
How similar studies have gone: Previous research has indicated interactions between THC and nicotine, suggesting that this approach could yield valuable insights into co-use behaviors.
Where this research is happening
-
Johns Hopkins University
Baltimore, United States Active
Researchers
- Principal investigator: Lee, Dustin Clark — Johns Hopkins University
- Study coordinator: Lee, Dustin Clark
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.