Investigating how cannabinoids affect the hidden HIV reservoir
Defining the impact of cannabinoids on the latent HIV reservoir through multi-omic analysis
This study is looking at how cannabinoids might affect hidden HIV in the body, which is important for finding new ways to help people living with HIV who use these substances.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of North Carolina Chapel Hill NIH-funded |
| Lab location | 1 site (Chapel Hill, United States) |
| Project ID | NIH-11045505 on NIH RePORTER |
What this research studies
This research explores the effects of cannabinoids on the latent HIV reservoir, which is a major challenge in curing HIV. The study aims to understand how cannabinoid exposure influences the size and characteristics of this reservoir in CD4 T cells, which are crucial for immune response. Using advanced techniques in single-cell multi-omic analysis, researchers will analyze the molecular changes induced by cannabinoids and their potential role in reactivating HIV from latency. This could lead to new strategies for managing HIV in patients who use cannabinoids.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV who also use cannabinoids.
Not a fit: Patients who do not use cannabinoids or are not living with HIV may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies for people living with HIV who use cannabinoids.
How similar studies have performed: While the specific impact of cannabinoids on the latent HIV reservoir is not well-studied, there is emerging evidence suggesting that cannabinoid effects on immune cells could influence HIV dynamics.
Where this research is happening
Chapel Hill, United States
- Univ of North Carolina Chapel Hill — Chapel Hill, United States (Active)
Researchers
- Principal investigator: Browne, Edward P — Univ of North Carolina Chapel Hill
- Study coordinator: Browne, Edward P
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.