Investigating how cannabidiol and terpenoids affect pain regulation in the brain
Cannabidiol and terpenoid interactions in amygdalar regulation of pain states
This study is looking at how CBD and terpenoids from cannabis might help people with chronic pain feel better without using opioids, by testing different combinations of these compounds in animals to see how they work in the brain.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-11004673 on NIH RePORTER |
What this research studies
This research explores the potential of cannabidiol (CBD) and terpenoids, compounds found in cannabis, to alleviate chronic pain without the use of opioids. The study will examine how specific combinations of CBD and terpenoids can provide both short-term and long-term pain relief by targeting the amygdala, a brain region involved in pain processing. Through a series of experiments, researchers will analyze the effects of these compounds on pain responses in animal models, aiming to uncover their mechanisms of action and potential therapeutic benefits for humans.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from chronic pain conditions who are seeking alternative pain management options.
Not a fit: Patients who do not experience chronic pain or those who are not interested in alternative therapies may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new, non-opioid treatments for chronic pain, reducing reliance on addictive pain medications.
How similar studies have performed: Previous research has shown promising results with cannabinoids in pain management, suggesting that this approach may be effective, although the specific combination of CBD and terpenoids is still being explored.
Where this research is happening
Seattle, United States
- University of Washington — Seattle, United States (Active)
Researchers
- Principal investigator: Land, Benjamin — University of Washington
- Study coordinator: Land, Benjamin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.