Investigating how cannabidiol affects stress regulation
Official title: Pathophysiological mechanisms of cannabidiol in stress regulation
Funded at Icahn School of Medicine at Mount Sinai · NIH-11108369 · Data updated 2026-11-12
This study is looking at how CBD might help young adults who are dealing with a lot of stress, to see if it can make it easier for them to handle stressful situations and improve their overall well-being.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | May 1, 2025 |
| Project end | February 28, 2030 |
| Funding year | 2025 |
| Award (this year) | $794,696 |
| NIH project number | 1R01MH139940-01 |
| Project ID | NIH-11108369 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are young adults aged 21 and older who experience stress-related disorders or heightened stress responses.
✕Less likely to help
Patients who do not experience stress-related disorders or who are not within the specified age range may not benefit from this research.
What this research studies
This research explores the effects of cannabidiol (CBD) on stress regulation, particularly in young adults who are at high risk for stress-related disorders. It aims to understand the mechanisms by which CBD interacts with the brain's stress response systems, including pathways that are often dysregulated in anxiety and stress disorders. By examining how CBD can modulate stress reactivity, the research seeks to identify new therapeutic strategies that could improve treatment outcomes for individuals suffering from stress-related issues. Participants may receive CBD and undergo assessments to evaluate its impact on their stress responses.
Why it matters
Potential benefit: If successful, this research could lead to new, effective treatments for managing stress and anxiety without the side effects associated with current medications.
How similar studies have gone: Previous studies have shown promising results regarding the anxiolytic effects of CBD, suggesting that this approach may be effective in treating stress-related disorders.
Where this research is happening
-
Icahn School of Medicine at Mount Sinai
New York, United States Active
Researchers
- Principal investigator: Bachi, Keren — Icahn School of Medicine at Mount Sinai
- Study coordinator: Bachi, Keren
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.