Investigating how Candida albicans affects the stress tolerance of Streptococcus mutans in dental health.
Official title: Exploring the role of C. albicans oxidative stress pathways in S. mutans reactive oxygen species tolerance
Funded at University of Florida · NIH-10996678 · Data updated 2026-11-12
This study looks at how two types of bacteria in your mouth, one that causes cavities and another that can help it survive, work together and how this might affect the way common mouthwashes and treatments work, with the goal of finding better ways to keep your teeth healthy.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project start | August 16, 2024 |
| Project end | August 15, 2026 |
| Funding year | 2024 |
| Award (this year) | $47,959 |
| NIH project number | 1F30DE034286-01 |
| Project ID | NIH-10996678 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with a history of dental caries or those at high risk for developing cavities.
✕Less likely to help
Patients who do not have dental caries or related oral health issues may not receive direct benefits from this research.
What this research studies
This research explores the interaction between two oral bacteria, Streptococcus mutans and Candida albicans, which are linked to dental caries. It focuses on how C. albicans enhances the ability of S. mutans to withstand oxidative stress, potentially impacting the effectiveness of common oral hygiene products like hydrogen peroxide. By studying these bacteria in co-culture, the research aims to understand their combined effects on oral health and the development of dental caries. Patients may benefit from insights that could lead to improved dental treatments and preventive measures.
Why it matters
Potential benefit: If successful, this research could lead to better strategies for preventing and treating dental caries, benefiting millions affected by this common condition.
How similar studies have gone: Previous research has shown that understanding the interactions between oral bacteria can lead to significant advancements in dental care, suggesting this approach has potential for success.
Where this research is happening
-
University of Florida
Gainesville, United States Active
Researchers
- Principal investigator: Katrak, Callahan Kashmira — University of Florida
- Study coordinator: Katrak, Callahan Kashmira
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.