Investigating how cancer-related mutations affect endometriosis
Role of cancer-associated mutations in endometriosis
This study is looking at how certain genetic changes might affect endometriosis, especially in women who don’t respond well to usual treatments, with the goal of finding better ways to diagnose and manage the condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-10626987 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of cancer-associated mutations in endometriosis, a condition affecting millions of women. It aims to identify genetic factors that contribute to the severity and types of endometriosis, particularly in cases that are resistant to standard hormonal treatments. By analyzing endometriotic lesions for specific mutations, the study seeks to develop better diagnostic and predictive markers, which could lead to improved management strategies for patients. The approach combines molecular biology techniques with clinical insights to enhance our understanding of this complex disease.
Who could benefit from this research
Good fit: Ideal candidates for this research include women diagnosed with endometriosis, especially those with deeply invasive forms of the disease.
Not a fit: Patients who do not have endometriosis or those with mild forms of the condition may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more accurate diagnoses and personalized treatment options for women suffering from endometriosis.
How similar studies have performed: There is emerging evidence that genetic factors play a significant role in endometriosis, suggesting that this research could build on previous findings and potentially lead to breakthroughs in understanding the disease.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Segars, James H. — Johns Hopkins University
- Study coordinator: Segars, James H.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.