Investigating how cancer progresses and how the immune system recognizes it using mouse models
Studying factors controlling cancer progression and immune recognition in mouse models
This study is looking at how lung and pancreatic cancers grow and how the immune system recognizes them, using advanced techniques to create models that act like real tumors, with the hope of finding new ways to improve cancer treatments.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts Institute of Technology NIH-funded |
| Lab location | 1 site (Cambridge, United States) |
| Project ID | NIH-10902077 on NIH RePORTER |
What this research studies
This research focuses on understanding the factors that influence cancer progression and immune recognition, particularly in lung and pancreatic cancers. By utilizing advanced genetic engineering techniques like CRISPR and single-cell analysis, the researchers aim to create detailed models that mimic human cancer behavior. They will analyze gene expression changes within tumors and their surrounding environment to uncover how tumors evolve and interact with the immune system. The findings could lead to new insights that may improve cancer treatment strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with lung adenocarcinoma or pancreatic ductal adenocarcinoma.
Not a fit: Patients with cancers other than lung or pancreatic adenocarcinoma may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective cancer therapies by enhancing our understanding of tumor behavior and immune interactions.
How similar studies have performed: Previous research using similar CRISPR-based approaches has shown promise in advancing our understanding of cancer biology and treatment.
Where this research is happening
Cambridge, United States
- Massachusetts Institute of Technology — Cambridge, United States (Active)
Researchers
- Principal investigator: Jacks, Tyler E. — Massachusetts Institute of Technology
- Study coordinator: Jacks, Tyler E.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.