Investigating how cancer metabolism affects gene regulation in pancreatic cancer
Metabolic compartmentalization and the regulation of histone propionylation in cancer
This study is looking at how certain changes in the way cancer cells use nutrients might affect their growth and behavior, specifically in a tough type of pancreatic cancer, to find new ways to treat it.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-11133834 on NIH RePORTER |
What this research studies
This research focuses on pancreatic ductal adenocarcinoma, a highly aggressive form of cancer, and explores how changes in metabolism influence gene regulation through modifications in histones. The study aims to understand the role of branched-chain amino acids in producing metabolites that affect chromatin structure and gene expression, which may contribute to tumor growth. By examining the mechanisms of how these metabolic changes occur within the nucleus of cancer cells, the research seeks to uncover new insights into cancer progression and potential therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with pancreatic ductal adenocarcinoma who are seeking innovative treatment options.
Not a fit: Patients with other types of cancer or those not diagnosed with pancreatic ductal adenocarcinoma may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatment strategies that target metabolic pathways to inhibit cancer growth.
How similar studies have performed: While the specific approach of linking metabolism and epigenetic regulation in pancreatic cancer is novel, similar research in other cancer types has shown promising results.
Where this research is happening
Philadelphia, United States
- University of Pennsylvania — Philadelphia, United States (Active)
Researchers
- Principal investigator: Wellen, Kathryn Elaine — University of Pennsylvania
- Study coordinator: Wellen, Kathryn Elaine
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.