Investigating how cancer cells interact with their environment to understand tumor growth and spread.
Core A: Pathobiology Core
This study is looking at how cancer cells interact with their surroundings to better understand how tumors grow and spread, with the hope of finding new, more effective treatments that are specially designed for each person's cancer.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11078878 on NIH RePORTER |
What this research studies
This research focuses on understanding the complex interactions between cancer cells and their surrounding environment, which can influence tumor growth and the spread of cancer. By using advanced techniques like single-cell sequencing, the study aims to identify the different genetic characteristics of tumors and how they change over time. The research will analyze both human tissue samples and mouse models to gain insights into how tumors develop resistance to treatments and how they metastasize. Patients may benefit from the findings that could lead to more effective therapies tailored to the unique characteristics of their cancer.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with prostate cancer, particularly those with local, castration-resistant, or neuroendocrine tumors.
Not a fit: Patients with non-cancerous conditions or those with cancers not related to prostate cancer may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies for cancer patients by providing insights into tumor behavior and resistance mechanisms.
How similar studies have performed: Other research has shown success in using single-cell sequencing to understand tumor heterogeneity and its implications for treatment, indicating that this approach is promising.
Where this research is happening
New York, United States
- Columbia University Health Sciences — New York, United States (Active)
Researchers
- Principal investigator: Loda, Massimo — Columbia University Health Sciences
- Study coordinator: Loda, Massimo
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.