Investigating how cancer cells adapt to stress through amyloid bodies
Official title: Amyloid-bodies and the Evolution of Malignancies
Funded at University of Miami School of Medicine · NIH-11063373 · Data updated 2026-11-12
This study is looking at how certain structures in cancer cells, called amyloid bodies, help those cells handle stress and grow, and it’s for anyone interested in understanding more about how tumors develop and what makes them tick.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Miami School of Medicine NIH-funded |
| Lab location | 1 site (Coral Gables, United States) |
| Project start | August 7, 2023 |
| Project end | July 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $76,750 |
| NIH project number | 3R01CA275828-02S1 |
| Project ID | NIH-11063373 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with various types of cancer who may benefit from understanding the mechanisms of tumor adaptation.
✕Less likely to help
Patients with non-cancerous conditions or those not diagnosed with any malignancies may not receive direct benefits from this research.
What this research studies
This research explores the role of amyloid bodies in cancer cells, particularly how they help these cells adapt to various stress conditions. The study focuses on a specific type of noncoding RNA that activates a program leading to the formation of amyloid bodies, which are unique cellular structures that can influence DNA synthesis and cell cycle control. By analyzing these structures, researchers aim to understand their impact on tumor development and the physiological processes involved. This research utilizes advanced proteomic analysis to identify the proteins involved in these processes.
Why it matters
Potential benefit: If successful, this research could lead to new insights into cancer biology and potential therapeutic targets for treating malignancies.
How similar studies have gone: While the concept of amyloid bodies in cancer is relatively novel, previous research has shown promising results in understanding cellular stress responses and their implications in cancer biology.
Where this research is happening
-
University of Miami School of Medicine
Coral Gables, United States Active
Researchers
- Principal investigator: Lee, Stephen — University of Miami School of Medicine
- Study coordinator: Lee, Stephen
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.