Investigating how cancer cells adapt to stress and survive treatment
Official title: Multiomic single cell and spatial interrogation of mechanisms in cellular adaptation to stress
Funded at University of Pennsylvania · NIH-11012307 · Data updated 2026-11-12
This study is looking at how cancer cells handle stress and find ways to survive treatment, with the hope of discovering new strategies to help patients overcome therapy resistance.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | February 1, 2024 |
| Project end | December 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $398,763 |
| NIH project number | 5R01GM149671-02 |
| Project ID | NIH-11012307 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients undergoing treatment for cancer who may experience therapy resistance.
✕Less likely to help
Patients with non-cancerous conditions or those not currently receiving cancer treatment may not benefit from this research.
What this research studies
This research focuses on understanding how cancer cells respond to stress and adapt to survive therapies. By using advanced techniques like single-cell analysis and lineage barcoding, the study aims to track the fate of individual cells during treatment. The goal is to identify the mechanisms that allow some cancer cells to resist therapy, which could lead to better treatment strategies. Patients may benefit from insights gained about how to overcome therapy resistance in cancer.
Why it matters
Potential benefit: If successful, this research could lead to more effective cancer treatments by targeting the mechanisms that allow cancer cells to survive therapy.
How similar studies have gone: Other research has shown success in using single-cell analysis to understand cancer biology, making this approach promising but still innovative.
Where this research is happening
-
University of Pennsylvania
Philadelphia, United States Active
Researchers
- Principal investigator: Zhang, Nancy R — University of Pennsylvania
- Study coordinator: Zhang, Nancy R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.