Investigating how cancer cells adapt to stress and survive treatment
Multiomic single cell and spatial interrogation of mechanisms in cellular adaptation to stress
This study is looking at how cancer cells handle stress and find ways to survive treatment, with the hope of discovering new strategies to help patients overcome therapy resistance.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-11012307 on NIH RePORTER |
What this research studies
This research focuses on understanding how cancer cells respond to stress and adapt to survive therapies. By using advanced techniques like single-cell analysis and lineage barcoding, the study aims to track the fate of individual cells during treatment. The goal is to identify the mechanisms that allow some cancer cells to resist therapy, which could lead to better treatment strategies. Patients may benefit from insights gained about how to overcome therapy resistance in cancer.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients undergoing treatment for cancer who may experience therapy resistance.
Not a fit: Patients with non-cancerous conditions or those not currently receiving cancer treatment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective cancer treatments by targeting the mechanisms that allow cancer cells to survive therapy.
How similar studies have performed: Other research has shown success in using single-cell analysis to understand cancer biology, making this approach promising but still innovative.
Where this research is happening
Philadelphia, United States
- University of Pennsylvania — Philadelphia, United States (Active)
Researchers
- Principal investigator: Zhang, Nancy R — University of Pennsylvania
- Study coordinator: Zhang, Nancy R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.