Investigating how cAMP signaling affects blood vessel function in health and disease
cAMP signaling in vascular smooth muscle in health and disease
This study is looking at how a molecule called cAMP affects blood vessel behavior, especially how it can both relax and tighten blood vessels, and it will explore how factors like gender and conditions such as diabetes and high blood pressure might change this process.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California at Davis NIH-funded |
| Lab location | 1 site (Davis, United States) |
| Project ID | NIH-10989958 on NIH RePORTER |
What this research studies
This research explores the role of a molecule called cAMP in regulating the function of vascular smooth muscle, which is crucial for blood vessel behavior. It challenges the traditional view that cAMP only causes blood vessel relaxation by examining how it can also promote contraction in response to glucose. The study will investigate how different factors, including biological sex, influence the production of cAMP in blood vessels and how these processes may be altered in conditions like diabetes and hypertension. By using advanced techniques in both human and mouse models, the research aims to uncover important insights into how cAMP signaling operates in health and disease.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with cardiovascular diseases, diabetes, or hypertension, as well as healthy volunteers for comparison.
Not a fit: Patients without any cardiovascular conditions or those not affected by diabetes or hypertension may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for cardiovascular diseases by improving our understanding of blood vessel function.
How similar studies have performed: Previous research has shown promising results in understanding cAMP signaling in vascular function, suggesting that this approach could yield valuable insights.
Where this research is happening
Davis, United States
- University of California at Davis — Davis, United States (Active)
Researchers
- Principal investigator: Navedo, Manuel F — University of California at Davis
- Study coordinator: Navedo, Manuel F
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.