Investigating how cAMP in cilia affects aneurysm formation
Official title: Cilia-specific cAMP plays a major role in aneurysm
Funded at Chapman University · NIH-10647751 · Data updated 2026-11-12
This study is looking at how a molecule called cAMP affects tiny hair-like structures on cells, which play a role in blood vessel health, especially concerning aneurysms, and it aims to see if blocking a certain enzyme can help these structures work better and possibly prevent aneurysms from forming.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Chapman University NIH-funded |
| Lab location | 1 site (Orange, United States) |
| Project start | July 15, 2020 |
| Project end | June 30, 2025 |
| Funding year | 2023 |
| Award (this year) | $345,000 |
| NIH project number | 5R01HL147311-04 |
| Project ID | NIH-10647751 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults over 21 years old who are at risk for or have been diagnosed with aneurysms.
✕Less likely to help
Patients who do not have aneurysms or related vascular conditions may not benefit from this research.
What this research studies
This research explores the role of cyclic adenosine monophosphate (cAMP) in the function of cilia, which are small hair-like structures on cells. The study uses innovative techniques like nanoparticle drug delivery and single-cell imaging to understand how changes in cAMP levels within cilia can influence vascular health, particularly in relation to aneurysms. By examining the effects of inhibiting a specific enzyme, phosphodiesterase-3 (PDE3), the researchers aim to determine if this can restore ciliary function and prevent aneurysm development. This could lead to new insights into how cilia contribute to vascular diseases.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for preventing or treating aneurysms.
How similar studies have gone: While the specific approach of targeting cilia with cAMP modulation is novel, related research has shown promise in understanding cilia's role in vascular health.
Where this research is happening
-
Chapman University
Orange, United States Active
Researchers
- Principal investigator: Nauli, Surya — Chapman University
- Study coordinator: Nauli, Surya
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.