Investigating how calcium signaling between cell organelles affects aging and age-related diseases
Targeting ER-mitochondrial calcium signaling to promote healthier aging
This study is looking at how two important parts of our cells, the endoplasmic reticulum and mitochondria, talk to each other as we get older, using tiny worms to see how this communication affects aging and related health issues, with hopes of finding new ways to help.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University NIH-funded |
| Lab location | 1 site (Nashville, UNITED STATES) |
| Project ID | NIH-11096048 on NIH RePORTER |
What this research studies
This research explores the connection between the endoplasmic reticulum (ER) and mitochondria, two vital cell organelles, to understand how their communication impacts aging and age-related diseases. By using a simple model organism, C. elegans, researchers will examine how calcium signaling from the ER influences mitochondrial health and function as organisms age. The study aims to uncover the mechanisms behind mitochondrial decline, which is linked to various age-related conditions, potentially leading to new therapeutic strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults experiencing age-related diseases or conditions, particularly those related to mitochondrial dysfunction.
Not a fit: Patients with acute or non-age-related conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that promote healthier aging and mitigate age-related diseases.
How similar studies have performed: Previous studies have shown promising results in understanding mitochondrial function and aging, suggesting that this approach could yield valuable insights.
Where this research is happening
Nashville, UNITED STATES
- Vanderbilt University — Nashville, United States (Active)
Researchers
- Principal investigator: Burkewitz, Kristopher — Vanderbilt University
- Study coordinator: Burkewitz, Kristopher
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.